甲氧基聚乙二醇氨基

甲氧基聚乙二醇氨基

【甲氧基聚乙二醇氨基的定義和作用】

mPEG-Amine is a linear methoxy PEG reagent with a reactive primary amine or NH2 group that can rapidly react with activated carboxyl acid such as NHS ester to form stable amide bonds. Amine can also react with carbonyl such as ketone and aldehyde.

比如：蛋白質(zhì)改性

原理

羧基肽和其它材料（-COOH）或其他與胺反應的化學基團。

抑制帶電分子在修飾表面的非特異性結(jié)合

【的參考文獻】

References:

1. Carboxyl PEGylation of Nanoparticles - Design and demonstration of a small-animal upconversion imager, Opt Express. 2008 December 22; 16(26): 21731–21737, Text.

2. Carboxyl PEGylation - Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations, Pharm Res (2011) 28:1112–1120, Text.

3. Carboxyl PEGylation - Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging, J Phys Condens Matter. 2010; 22(19): 194121, Text.

4. Carboxyl PEGylation of Nanoparticles - Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues, Mol Pharm. 2013 June 3; 10(6): 2176–2182, Text.

5.Carboxyl PEGylation of Nanoparticles- Nanoparticle diffusion in respiratory mucus from humans without lung disease, Biomaterials. 2013 April ; 34(13): 3439–3446, Text.

【的保存】

取用時需要干燥，溶解和凍干不能太過頻繁

-20℃ 密封存放，有條件的話充惰性氣體保存。

【的理化性質(zhì)】

溶于大部分有機溶劑

DCM、DMF、DMSO、THF

H2O

【甲氧基聚乙二醇有哪些類型】

mPEG-Amine, MW 1k

mPEG-Amine, MW 20k

mPEG-Amine, MW 350

mPEG-Amine, MW 550

mPEG-Amine, MW 30K

mPEG-Amine, MW 5k

mPEG-Amine, MW 2k

mPEG-Amine, MW 10k

【有哪些公司可以生產(chǎn)定制供應】

上海子起生物科技有限公司：

接受修飾性PEG常規(guī)分子量、常規(guī)基團的的定制和服務

支持發(fā)貨隨核磁等資質(zhì)文件

支持*質(zhì)量售后

【甲氧基聚乙二醇關(guān)聯(lián)基團/官能團有哪些？】

磷脂-DSPE

巰基-SH

丙烯酸酯/丙烯酰-DA ACRL

疊氮聚乙二醇-N3

馬來酰亞胺化聚乙二醇-MAL

同雙官能團修飾性聚乙二醇

氨基化聚乙二醇-NH2

羧基聚乙二醇

氨基聚乙二醇

馬來酰亞胺聚乙二醇

活性酯聚乙二醇

丙烯酰、丙烯酸酯聚乙二醇

疊氮聚乙二醇

生物素聚乙二醇

磷脂（DSPE）-聚乙二醇

單官能團修飾性聚乙二醇

甲氧基聚乙二醇衍生物

同雙官能團聚乙二醇衍生物

異雙官能團聚乙二醇衍生物

巰基聚乙二醇