Mdivi-1 Sigma
Mdivi-1 Sigma
產(chǎn)品描述
General description
Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable.[2] It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.[3]
Application
Mdivi-1 has been used:
• in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation[1]
• in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)[4]
• to induce mitochondrial damage in lung fibroblasts[5]
包裝
5, 25 mg in glass bottle
Biochem/physiol Actions
Mdivi-1是線粒體DRP(發(fā)動(dòng)蛋白相關(guān)GTP酶)分裂選擇性抑制劑以及線粒體分裂發(fā)動(dòng)蛋白(Dnm1)抑制劑。線粒體融合和分裂在細(xì)胞凋亡調(diào)節(jié)中有很重要的作用。Mdivi-1代表了一系列用于治療中風(fēng),心肌梗塞和神經(jīng)退行性疾病的藥物。
Features and Benefits
該化合物是細(xì)胞凋亡研究的特色產(chǎn)品。點(diǎn)擊此處 ,查看更多細(xì)胞凋亡精選產(chǎn)品。
性質(zhì)
Related Categories | Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, M, 生物活性小分子, 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和神經(jīng)科學(xué), 細(xì)胞生物學(xué) Less... |
Quality Level | 100 |
assay | ≥98% (HPLC) |
form | powder |
solubility | DMSO: >20 mg/mL |
shipped in | wet ice |
storage temp. | −20°C |
SMILES string | COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl |
InChI | 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22) |
InChI key | NZJKEVWTYMOYOR-UHFFFAOYSA-N |