GS15083
Protein
Uniprot ID:P10820 (21-554aa)
PRF1, PFN1, PRO1, At2g19760, F6F22.21
E.coli
Mus musculus (house mouse)
N-terminal Sumo-tagged；N-terminal His-tagged；
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-141℃.
For research use only
該蛋白在分泌顆粒依賴性細胞死亡和防御病毒感染或腫瘤細胞中起關(guān)鍵作用。在殺死其他被免疫系統(tǒng)識別為非自身的細胞中起重要作用，例如在移植排斥反應(yīng)或某些形式的自身免疫性疾病中。能以鈣結(jié)合形式插入靶細胞膜，寡聚并形成大孔。通過促進細胞毒性顆粒酶的攝取促進靶細胞的細胞溶解和凋亡。
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