LY294002 抑制劑
注:本產(chǎn)品僅用于科研,不可用于臨床
生物活性 | LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4?μM. LY294002 is an apoptosis activator[3]. | ||||||||||||||||||
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IC50 & Target[1][2][4] |
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體外研究 (In Vitro) | LY294002 (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[4]
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體內(nèi)研究 (In Vivo) | LY294002 (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 | 307.34 | ||||||||||||||||||
性狀 | Solid | ||||||||||||||||||
Formula | C19H17NO3 | ||||||||||||||||||
CAS 號(hào) | 154447-36-6 | ||||||||||||||||||
運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||
儲(chǔ)存方式 |
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溶解性數(shù)據(jù) | In Vitro: DMSO : 50 mg/mL (162.69 mM; Need ultrasonic) Ethanol : 50 mg/mL (162.69 mM; Need ultrasonic) 配制儲(chǔ)備液
* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。 In Vivo: 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑: ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
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