注:本產(chǎn)品僅用于科研,不可用于臨床
Lipopolysaccharides試劑生物活性
ipopolysaccharides (LPS)是一種內(nèi)毒素來(lái)源于外層膜的外膜革蘭氏陰性細(xì)菌。脂多糖由抗原O-specific鏈,一個(gè)核心的低聚糖和脂質(zhì)a脂多糖是一種病原相關(guān)分子模式(PAMP時(shí)),激活免疫系統(tǒng)。脂多糖對(duì)免疫細(xì)胞激活地[1][2][3]。這個(gè)產(chǎn)品來(lái)源于大腸桿菌O55: B5。脂多糖誘導(dǎo)的分泌細(xì)胞migrasome
Lipopolysaccharides試劑 IC50 & Target
TLR4
體外研究 (In Vitro) | Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production)[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
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體內(nèi)研究 (In Vivo) | Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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性狀 | Solid | ||||||||||||
中文名稱 | 脂多糖 | ||||||||||||
結(jié)構(gòu)分類 |
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初始來(lái)源 | surface of Gram-negative bacteria | ||||||||||||
運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
儲(chǔ)存方式 |
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溶解性數(shù)據(jù) | In Vitro: H2O : 5 mg/mL (Need ultrasonic) In Vivo: 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑: ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
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