注：本產(chǎn)品僅用于科研，不可用于臨床
Trichostatin A 抑制劑簡(jiǎn)介
Trichostatin A (TSA) 是有效的，特異的組蛋白去乙酰化酶類型 I 和 II (HDAC class I/II) 抑制劑，對(duì) HDAC 的 IC50 值為 1.8 nM。
Trichostatin A 抑制劑生物活性
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC
| C50 & Target[1] |
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| 體外研究 (In Vitro) | Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC50 of 124.4±120.4 nM (range, 26.4-308.1 nM). HDAC inhibitory activity of Trichostatin A is similar in all cell lines with mean IC50 of 2.4±0.5 nM (range, 1.5-2.9 nM)[1]. Trichostatin A (330 nM) increases Gαs protein expression in human myometrial cells, but does not increase Gαs mRNA levels[2]. Trichostatin A (20-75?nM) induces minimal cytotoxicity to adipose-derived stem cells (ADSCs), and enhances the osteogenic differentiation capacity of ADSCs[3]. In addition, Trichostatin A (0, 10, 100, 500 nM) dose-dependently decreases HDAC class I/II activity[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 體內(nèi)研究 (In Vivo) | Trichostatin A (500 μg/kg, s.c.) pronounces antitumor activity without causing any measurable toxicity in doses of up to 5 mg/kg by s.c. injection, in randomized controlled efficacy studies using the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 分子量 | 302.37 | ||||||||||||||||
| 性狀 | Solid | ||||||||||||||||
| Formula | C17H22N2O3 | ||||||||||||||||
| CAS 號(hào) | 58880-19-6 | ||||||||||||||||
| 中文名稱 | 曲古抑菌素A | ||||||||||||||||
| 結(jié)構(gòu)分類 |
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| 運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 儲(chǔ)存方式 |
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| 溶解性數(shù)據(jù) | In Vitro: DMSO : 25 mg/mL (82.68 mM; Need ultrasonic) 配制儲(chǔ)備液
* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。 In Vivo: 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑： ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
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