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當(dāng)前位置:杭州昊鑫生物科技股份有限公司>>MCE>>生物試劑>> HY-17394Cisplatin試劑
HY-17394
MCE
代理商
杭州市
100 mg 420元 10000支可售
500 mg 1100元 10000支可售
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更新時(shí)間:2023-05-22 14:03:33瀏覽次數(shù):203次
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生物活性 | |||||||||||||||||||||
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IC50 & Target | DNA Alkylator/Crosslinker[1] | ||||||||||||||||||||
體外研究 (In Vitro) | Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||||||
體內(nèi)研究 (In Vivo) | In melanoma-bearing mice, Cisplatin (CDDP; 4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||||||
Clinical Trial |
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分子量 | 300.05 | ||||||||||||||||||||
性狀 | Solid | ||||||||||||||||||||
Formula | Cl2H6N2Pt | ||||||||||||||||||||
CAS 號(hào) | 15663-27-1 | ||||||||||||||||||||
中文名稱 | |||||||||||||||||||||
運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
儲(chǔ)存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||||||
溶解性數(shù)據(jù) | In Vitro: DMF : 5 mg/mL (16.66 mM; Need ultrasonic; DMSO can inactivate Cisplatin's activity) H2O : 1 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Cisplatin's activity) 配制儲(chǔ)備液
* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。 In Vivo: 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑: ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
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注:本產(chǎn)品僅用于科研,不可用于臨床
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