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Lipopolysaccharides試劑返回列表頁(yè)

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型號(hào)
HY-D1056
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

5 mg 1320元 10000可售

10 mg 2200元 10000可售

25 mg 4800元 10000可售

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注：本產(chǎn)品僅用于科研，不可用于臨床

Lipopolysaccharides試劑生物活性

ipopolysaccharides (LPS)是一種內(nèi)毒素來(lái)源于外層膜的外膜革蘭氏陰性細(xì)菌。脂多糖由抗原O-specific鏈,一個(gè)核心的低聚糖和脂質(zhì)a脂多糖是一種病原相關(guān)分子模式(PAMP時(shí)),激活免疫系統(tǒng)。脂多糖對(duì)免疫細(xì)胞激活地[1][2][3]。這個(gè)產(chǎn)品來(lái)源于大腸桿菌O55: B5。脂多糖誘導(dǎo)的分泌細(xì)胞migrasome

Lipopolysaccharides試劑 IC₅₀ & Target

TLR4

體外研究
(In Vitro)

Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production)^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female and male CD1 mice^[3]
Dosage:	1.5mg/kg
Administration:	Intraperitoneal injection, once
Result:	Induced sickness behavior in all mice, but adult mice displayed more sickness than pubertal mice and adult males remained sick for a longer period of time than adult females. Caused a decrease in body temperature for all mice, but this decrease was greatest in adult males. Increased pro- and anti-inflammatory cytokines at various levels in pubertal and adult male and female mice, resulted in age and sex differences in cytokine concentrations following immune challenge. Only adult males and females treated with LPS displayed significantly more IL-6 than their saline controls, and pubertal males and females and adult females displayed significantly more IL-10 than their saline controls. All the mice displayed significantly more IL-12 and TNF-α than their saline controls.

性狀

Solid

中文名稱

脂多糖

結(jié)構(gòu)分類

Saccharides

初始來(lái)源

surface of Gram-negative bacteria

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

In Vitro:

H₂O : 5 mg/mL (Need ultrasonic)

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
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