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DBCO-Acid,二苯基環(huán)辛炔-羧酸,1353016-70-2,DBCO-COOH的分子式
結(jié)構(gòu)式：
試劑簡介：
Molecular weight | 305.11 |
Molecular formula | C19H15NO3 |
CAS | 1353016-70-2 |
Solubility | DMSO, DMF |
Purity | >95% (HPLC) |
Appearance | Slightly grey crystalline |
Storage Conditions | -20°C |
Shipping conditions | Ambient temperature |
DBCO-Acid,二苯基環(huán)辛炔-羧酸,1353016-70-2,DBCO-COOH的分子式
應(yīng)用介紹：
An analog of DBCO-Acid with improved stability and solubility in monly used organic solvents.
DBCO reagents, also known as ADIBO or DIBAC are routinely used building blocks for synthesis of plex molecules to be used in Cu-free ligation applications.
Using DBCO-C6-Acid primary or secondary amines can be easily functionalized with DBCO moiety in the presence of activators (e.g. EDC, or HATU) through a stable amide bond. A longer carbon spacer arm improves stability and solubility of this reagent in monly used organic solvents.
供應(yīng)商：西安凱新生物科技有限公司
地址(Address):中國·西安·蓮湖區(qū)興中路3號
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其它點擊類試劑：
名稱：DBCO-NHS Ester MW：402.40
英文介紹：
DBCO-NHS Ester reacts with primary amines
This product is not remended for labeling of proteins or any other biopolymers in aueous buffers due to poor aueous solubility.
名稱：PC DBCO-NHS Ester,Photocleavable DBCO-NHS ester 的結(jié)構(gòu)式 MW:945.96
英文介紹：
An amine-reactive, photocleavable labeling reagent.
Photocleavable DBCO-NHS ester reagent contains an amine reactive group linked to DBCO moiety through a spacer arm containing a photocleavable moiety. Molecules jointed by the copper-free click reaction can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).
名稱：DBCO-PEG5-NHS Ester MW:693.74
英文簡介：
An amine-reactive labeling reagent with enhanced water stability and solubility.
DBCO-PEG5-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to plementary azide-containing molecules.
名稱：DBCO-PEG4-NHS Ester MW:649.68
英文簡介：
An amine-reactive labeling reagent with enhanced water solubility provided by a PEG4 spacer.
DBCO-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to plementary azide-containing molecules.
名稱：DBCO-Sulfo-NHS Ester MW:532.50
英文簡介：
A water-soluble reagent for labeling antibodies, proteins and other molecules containing primary amines.
DBCO-Sulfo-NHS-Ester enables simple and efficient labeling of antibodies, proteins and any other primary amine-containing macromolecules with DBCO moiety. This reagent is water-soluble, enabling labeling to be performed in the absence of organic solvents such as DMSO or DMF for applications that cannot tolerate solvents or are plicated by their inclusion. Specific labeling of cell surface proteins is another mon application for these uniuely water-soluble and membrane impermeable reagents.
名稱：DBCO-Acid MW:305.11
英文簡介：
DBCO-Acid is an amine reactive, non-activated cyclooctyne building block.
The use of strained cyclooctynes instead of terminal alkynes allows for overing a major drawback of copper-catalyzed azide-alkyne cycloaddition (CuAAC) - the need for the toxic copper catalyst. The ring strain in cyclooctynes, such as DBCO-Acid makes them highly reactive in the cycloaddition reaction. This reaction was termed as the strain-promoted alkyne-azide cycloaddition (SPAAC) or copper-free click reaction and has been widely used for bioconjugation and for labeling living cells and living animals.
名稱：DBCO-PEG5-Acid MW:596.67
英文簡介：
An amine-reactive building block with enhanced stability and solubility in aueous media.
DBCO-PEG5-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules pared to reagents having only hydrocarbon spacers. The PEG spacer arm also gives the reagent a long and flexible connection to minimize steric hindrance involved with reacting with plementary azido-modified molecules.
名稱：DBCO-PEG4-Acid MW:552.62
英文簡介：
An amine-reactive building block with enhanced solubility in aueous media.
DBCO-PEG4-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules pared to reagents having only hydrocarbon spacers
名稱：DBCO-PEG4-4-Formylbenzoate MW:655.77
英文簡介：
A heterobifunctional reagent for labeling aminooxy-containing pounds.
DBCO-PEG4-4-Formylbenzoate reacts specifically and efficiently with an aminooxy group at pH 4-5 to form a covalent oxime bond. The oxime ligation with aromatic aldehydes is highly chemoselective and is patible with other functional groups present in peptides or biomolecules. An aniline catalysis can be used to activate aromatic aldehyde towards an aminooxy group and greatly enhance the rate of ligation reaction.
DBCO Reagents-Carboxyl/Carbonyl Reactive產(chǎn)品詳細(xì)英文介紹和使用說明：
名稱：DBCO-Amine MW:276.33 CAS:1255942-06-3
英文簡介：
A carboxyl-reactive building block containing DBCO moiety and a terminal primary amine group.
DBCO-Amine is a simple DBCO-containing reagent possessing a terminal primary amines group (–NH2) that reacts with carboxyl groups in the presence of activators (e.g. EDC, or DCC) or with activated esters (e.g. NHS esters) forming stable amide bonds. A short spacer arm adds minimal mass to modified molecules (273.3 daltons).
名稱：DBCO-PEG4-Amine MW:523.62
英文簡介：
A carbonyl-reactive building block with enhanced solubility in aueous media.
DBCO-PEG4-Amine is a polyethylene glycol-containing reagent with terminal primary amines (–NH2) that reacts with carboxyl groups in the presence of activators (e.g. EDC, or DCC) or with activated esters (e.g. NHS esters) forming stable amide bonds. A hydrophilic spacer arm enhances solubility in aueous buffers.
名稱：ThioLinker-DBCO
英文簡介：
A uniue, water-soluble, bis-alkylating reagent that allows for site-specific labeling of antibodies under mild aueous conditions.
The traditional sulfhydryl labeling chemistry cleaves disulfide bridges and leaves them in &lduo;open form&rduo;, which may promise the stability and function of an antibody or other proteins. ThioLinkerTM-DCBO re-bridges the disulfide bond, and enhances the structural stability of the protein. In addition, conjugates prepared with ThioLinkerTM reagents benefits from reduced heterogeneity and better stability.
名稱：DBCO-Maleimide MW:427.75
英文簡介：
A short-length, sulfhydryl-reactive labeling reagent that contains a short hydrocarbon spacer.
DBCO-Maleimide enables simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. A short spacer arm adds minimal mass to modified molecules (427.4 daltons).
名稱：DBCO-PEG4-Maleimide MW:674.74
英文簡介：
A mid-length, sulfhydryl-reactive labeling reagent with enhanced water solubility provided by a PEG4 spacer.
DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in the solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to plementary azide-containing molecules.
名稱：Bis-sulfone-PEG4-DBCO MW：1006.19
英文簡介：
A bis-alkylating labeling reagent used to create conjugates with enhanced structural stability.
Bis-sulfone-PEG4-DBCO enables site-specific incorporation of DBCO moiety onto antibodies to form well defined conjugates. Unlike conjugates prepared through conventional, maleimide-based labeling chemistry that leaves disulfide bridges in &lduo;open form&rduo; and produces a heterogeneous mixture labeled species with DAR 1-8, conjugates prepared with bis-sulfone reagents benefits from reduced heterogeneity and enhanced stability.
名稱：Bis-sulfone-PEG3-Azide MW:700.82
英文簡介：
A bis-alkylating labeling reagent used to create well-defined conjugates with enhanced structural stability.
Bis-sulfone-PEG3-Azide enables site-specific incorporation of an azide group onto antibodies to form well defined conjugates. Unlike conjugates prepared through conventional, maleimide-based labeling chemistry that leaves disulfide bridges in &lduo;open form&rduo; and produces a heterogeneous mixture labeled species with DAR 1-8, conjugates prepared with bis-sulfone reagents benefits from reduced heterogeneity and enhanced stability.
DBCO Reagents-Bifunctional Crosslinkers產(chǎn)品詳細(xì)英文介紹和使用說明：
名稱：DBCO-PEG4-DBCO MW:854.92
英文簡介：
An azide-to-azide homobifunctional cross-linker with a hydrophilic PEG4 spacer arm.
DBCO-PEG4-DBCO reacts specifically and efficiently with an azide group (e.g., a side chain of L-azidohomoalanine) to form a stable triazole moiety.
名稱：TCO-PEG12-DBCO
英文簡介：
An azide-to-tetrazine heterobifunctional cross-linker with a hydrophilic PEG12 spacer arm.
Heterobifunctional reagents are used for converting azido-containing biomolecules into TCO-modified biomolecules. TCO-PEG12-DBCO can serve as a heterobifunctional azide-to-tetrazine cross-linker for covalently linking azido- and tetrazine-modified peptides or biopolymers. The PEG12 spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to plementary reagent.
名稱：Methyltetrazine-DBCO
英文簡介：
A water-soluble azide-to-TCO heterobifunctional crosslinker.
Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. Tetrazine-DBCO can serve as a heterobifunctional azide-to-TCO cross-linker for covalently linking azido- and TCO-modified peptides or biopolymers.
名稱：Tetrazine-PEG12-DBCO
英文簡介：
An azide-to-TCO heterobifunctional crosslinker with a hydrophilic PEG12 spacer arm.
Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. Tetrazine-PEG12-DBCO can serve as a heterobifunctional azide-to-TCO cross-linker for covalently linking azido- and TCO-modified peptides or biopolymers.
名稱：DBCO-PEG4-4-Formylbenzoate
英文簡介：
A heterobifunctional reagent for labeling aminooxy-containing pounds.
DBCO-PEG4-4-Formylbenzoate reacts specifically and efficiently with an aminooxy group at pH 4-5 to form a covalent oxime bond. The oxime ligation with aromatic aldehydes is highly chemoselective and is patible with other functional groups present in peptides or biomolecules. An aniline catalysis can be used to activate aromatic aldehyde towards an aminooxy group and greatly enhance the rate of ligation reaction.
名稱：DBCO-PEG4-Biotin
英文簡介：
An azide-reactive biotinylation reagent with an extended PEG4 spacer arm.
DBCO reacts with an azide to produce a stable triazole, also referred to as the Cu(I)‐free or strain-promoted click reaction. The azide group, which is the reactive target of DBCO-activated biotin, can be introduced into proteins or other cellular targets via azide labeling reagents or through in vivo labeling with azide-derivatives of naturally occurring metabolic building blocks. This reaction possesses extreme selectivity and biopatibility, such that the plimentary reagents can form covalent bonds within richly functionalized biological systems, and, in some cases, living organisms.
名稱：WS DBCO-Biotin
英文簡介：
A water-soluble, azide-reactive biotinylation reagent.
DBCO reacts with an azide to produce a stable triazole, also referred to as the Cu(I)‐free or strain-promoted click reaction. The azide group, which is the reactive target of DBCO-activated biotin, can be introduced into proteins or other cellular targets via azide labeling reagents or through in vivo labeling with azide-derivatives of naturally occurring metabolic building blocks. This reaction is extremely selective and biopatible, such that the plimentary reagents can form a covalent bond within richly functionalized biological systems, and, in some cases, living organisms.
名稱：photoclevable DBCO-Biotin
英文簡介：
An azide-reactive, photoclevable biotin probe that allows for reagent-free release of the captured biomolecules from streptavidin.Extraordinary strength of the streptavidin-biotin interaction allows for efficient capturing of even highly dilute targets; however, it makes recovery of proteins from affinity resins challenging.
名稱：DBCO-PEG4-Desthiobiotin
英文簡介：
An azide-reactive desthiobiotin reagent that allows easy elution from streptavidin.
Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly eual specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Conseuently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on petitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein plexes with free biotin.
名稱：WS-PC DBCO-Biotin
英文簡介：
A water-soluble, photoclevable biotin probe that allows for reagent-free release of the captured biomolecules from streptavidin.
Extraordinary strength of the streptavidin-biotin interaction allows for efficient capturing of even highly dilute targets; however, it makes recovery of proteins from affinity resins challenging. Photocleavable biotin probes eliminate a major limitation of the streptavidin-biotin affinity purification. This reagent contains a biotin moiety linked to an azide moiety through a spacer arm containing a photocleavable moiety. Captured biomolecules can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).
名稱：Dde Biotin-DBCO
英文簡介：
A hydrazine cleavable biotinylation reagent for selective enrichment of azide-tagged biopolymers via SPAAC reaction.
Extraordinary strength of the streptavidin-biotin interaction allows for efficient capturing of even highly dilute targets; however, it makes recovery of proteins from affinity resins challenging. Dde Biotin-DBCO probe eliminates a major limitation of the streptavidin-biotin affinity purification. This reagent contains a biotin moiety linked to an alkyne moiety through a spacer arm containing a Dde linker. Captured biomolecules can be efficiently released, typically >90%.
名稱：Diazo Biotin-DBCO
英文簡介：
A sodium dithionite (Na2S2O4) cleavable biotinylation reagent for selective enrichment of azide-tagged biopolymers via SPAAC reaction.
Diazo Biotin-DBCO allows capture of azide-tagged biomolecules via the Cu-free click reaction under mild aueous buffer conditions. This reaction possesses extreme biopatibility, such that the plementary reagents can form covalent bonds within living organisms. Biotinylated protein targets can be selectively captured through conventional affinity purification protocols that exploit the biotin - streptavidin interaction. Captured protein targets can be released under mild conditions with 50 mM sodium dithionite solution, and identified by mass spectrometry, ELISA, dot blot, or Western blot applications.
名稱：DBCO-S-S-PEG3-Biotin
英文簡介：
A cleavable biotinylation reagent for specific enrichment azide-tagged biomolecules.
DBCO-S-S-PEG3-Biotin enables simple and efficient biotin labeling of azide-tagged antibodies, proteins and other macromolecules. The DBCO group reacts with an azide to produce an stable triazole, which is also referred to as the Cu(I)-free or strain-promoted click reaction. The hydrophilic PEG spacer arm imparts water solubility and reduces aggregation of labeled proteins stored in the solution. The integral disulfide bond enables the biotin group to be cleaved from the labeled molecule using DTT or other reducing agents.
名稱：Carboxyrhodamine 110 DBCO
英文簡介：
A green fluorescence-emitting probe with excitation/emission maximum of 501/523 nm
DBCO-activated Carboxyrhodamine110 dye reacts with azides to produce a stable triazole, also referred to as the Cu-free click reaction, and does not reuire Cu-catalyst or elevated temperatures. This reaction is extremely selective and biopatible, such that the plimentary reagents can form a covalent bond within richly functionalized biological systems, and, in some cases, living organisms.
名稱：Sulforhodamine B DBCO
英文簡介：
A red fluorescence-emitting probe with excitation/emission maximum of 568/585 nm
DBCO-activated Sulforhodamine B dye reacts with azides to produce a stable triazole, also referred to as the Cu-free click reaction, and does not reuire a Cu-catalyst or elevated temperatures. This reaction possesses extreme selectivity and biopatibility, such that the plimentary reagents can form covalent bonds within richly functionalized biological systems, and, in some cases, living organisms.
名稱：TAMRA DBCO
英文簡介：
An orange-to-red fluorescence-emitting probe with excitation/emission maximum of 554/567 nm
DBCO-activated TAMRA dye reacts with azides to produce a stable triazole, also referred to as the Cu-free click reaction, and does not reuire Cu-catalyst or elevated temperatures. This reaction possesses extreme selectivity and biopatibility, such that the plimentary reagents can form covalent bonds within richly functionalized biological systems, and, in some cases, living organisms.
名稱：Sulforhodamine 101 DBCO
英文簡介：
A red fluorescence-emitting probe with excitation/emission maximum of 5/601 nm
DBCO-activated Sulforhodamine 101 dye reacts with azides to produce a stable triazole, also referred to as the Cu-free click reaction, and does not reuire a Cu-catalyst or elevated temperatures. This reaction is extremely selective and biopatible, such that the plimentary reagents can form covalent bonds within richly functionalized biological systems, and, in some cases, living organisms.
名稱：Cy3 DBCO
英文簡介：
An azide-reactive Cy3 dye for chemoselective labeling and detection of azido-tagged molecules via the Cu-free click reaction.
名稱：Cy5 DBCO
英文簡介：
A water-soluble, azide-reactive Cy5 dye for chemoselective labeling and detection of azido-tagged molecules via the Cu-free click reaction.
名稱：Cy5.5 DBCO
英文簡介：
An azide-reactive, water soluble Cy5.5 dye for chemoselective labeling and detection of azido-tagged molecules.
名稱：Cy7 DBCO
英文簡介：
An azide-reactive, water-soluble Cy7 dye for chemoselective labeling and detection of azido-tagged molecules via the Cu-free click reaction.
名稱：DBCO-PEG4-Phosphoramidite
英文簡介：
DBCO-PEG4-Phosphoramidite is a reagent for incorporation of DBCO moiety onto an oligonucleotide for subseuent copper-free click elaboration.
名稱：DBCO-PEG4-Hydroxyl
英文簡介：
A modification reagent containing a long 4-unit polyethylene glycol (PEG4) spacer arm and a terminal primary hydroxyl group.
西安凱新生物科技有限公司是國內(nèi)專業(yè)的點擊化學(xué)試劑供應(yīng)商，產(chǎn)品廣泛應(yīng)用于各大科研院校、檢驗機構(gòu)、環(huán)境監(jiān)測、生物制藥、石油化工、航天技術(shù)、公共安全等眾多領(lǐng)域。我公司提供的點擊類化學(xué)試劑包括：DBCO、TCO、Tetrazine、Azide、Alkyne、Auxiliary reagents等。其中DBCO Reagents又包含了與氨基反應(yīng)的，與羧基反應(yīng)的，與生物素交聯(lián)的，與熒光素交聯(lián)的，與PEG交聯(lián)的等等產(chǎn)品。各試劑具有多樣的規(guī)格和齊全的包裝，能滿足您各類實驗需求，西安凱新所有員工希望能與您攜手共進，共創(chuàng)輝煌。
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