細(xì)胞自噬(autophagy or autophagocytosis):又稱為Ⅱ型細(xì)胞死亡,是細(xì)胞在自噬相關(guān)基因(autophagyrelated gene,Atg)的調(diào)控下利用溶酶體降解自身受損的細(xì)胞器和大分子物質(zhì)的過程。目前發(fā)現(xiàn)自噬在重要的生物過程中,如細(xì)胞生長、細(xì)胞分化、天然和適應(yīng)性免疫、老化和細(xì)胞死亡等都發(fā)揮著很重要的作用。
啟因生物是一家專業(yè)提供生命醫(yī)學(xué)前沿研究技術(shù)及整體信息解決方案的高科技企業(yè)。致力于為生命醫(yī)學(xué)領(lǐng)域的研究創(chuàng)新和成果轉(zhuǎn)化提供技術(shù)及市場方案。 公司擁有高通量實(shí)時(shí)熒光定量PCR服務(wù)平臺(tái),并已優(yōu)化和建立了基因定量檢測引物數(shù)據(jù)庫(已超過5000 種基因),*提高實(shí)驗(yàn)效率,降低實(shí)驗(yàn)成本。依托此平臺(tái),可以提供抗性基因,功能基因,非編碼RNA(lncrna和microrna),PCR芯片以及上百種細(xì)胞信號(hào)通路相關(guān)基因的PCR芯片等多種PCR芯片的技術(shù)服務(wù).
檢測樣品:組織 細(xì)胞 RNA CDNA
種屬:人
優(yōu)勢:定量PCR原理,只需提供樣品,數(shù)量不限,免費(fèi)數(shù)據(jù)分析
價(jià)格:1360元/樣 *活動(dòng)價(jià):1000元/樣
實(shí)驗(yàn)周期:收到樣品起,兩周左右
檢測指標(biāo)數(shù)目:84個(gè)
Autophagy Machinery Components:
Genes Involved in Autophagic Vacuole Formation: AMBRA1 (NYW1), ATG12, ATG16L1, ATG4A, ATG4B, ATG4C, ATG4D, ATG5, ATG9A, ATG9B, BECN1, GABARAP, GABARAPL1, GABARAPL2, IRGM, MAP1LC3A, MAP1LC3B, RGS19, ULK1, WIPI1.
Genes Responsible for Protein Targeting to Membrane / Vacuole: ATG4A, ATG4B, ATG4C, ATG4D, GABARAP.
Genes Responsible for Protein Transport: ATG10, ATG16L1, ATG16L2, ATG3, ATG4A, ATG4B, ATG4C, ATG4D, ATG7, ATG9A, GABARAP, GABARAPL2, RAB24.
Genes Linking Autophagosome to Lysosome: DRAM1, GABARAP, LAMP1, NPC1.
Genes Involved in Protein Ubiquitination: ATG3, ATG7, HDAC6.
Genes with Protease Activity: ATG4A, ATG4B, ATG4C, ATG4D.
Regulation of Autophagy:
Co-Regulators of Autophagy and Apoptosis: AKT1, APP, ATG12, ATG5, BAD, BAK1, BAX, BCL2, BCL2L1 (BCL-X), BECN1, BID, BNIP3, CASP3, CASP8 (FLICE), CDKN1B (p27KIP1), CDKN2A (p16INK4), CLN3, CTSB, CXCR4, DAPK1, DRAM1, EIF2AK3, FADD, FAS (TNFRSF6), HDAC1, HTT, IFNG, IGF1, INS, MAPK8 (JNK1), MTOR, NFKB1, PIK3CG, PRKAA1, PTEN, SNCA, SQSTM1, TGFB1, TGM2, TNF, TNFSF10 (TRAIL), TP53.
Co-Regulators of Autophagy and the Cell Cycle: BAX, CDKN1B (p27KIP1), CDKN2A (p16INK4), IFNG, PTEN, RB1, TGFB1, TP53.
Autophagy Induction by Intracellular Pathogens: EIF2AK3, IFNG, LAMP1.
Autophagy in Response to Other Intracellular Signals: CTSD, CTSS, DRAM2 (TMEM77), EIF4G1, ESR1 (ERa), GAA, HGS, MAPK14, PIK3C3 (VPS34), PIK3R4, RPS6KB1, TMEM74, ULK2, UVRAG.
Chaperone-Mediated Autophagy: HSP90AA1, HSPA8.