脊髓損傷（SCI）研究的利器
(MASCIS Impactor,NYU Impactor)脊髓損傷撞擊器是設計用來為大小鼠施加可重復的標準脊椎撞擊。已經(jīng)開發(fā)應用超過十年，它是嚙齒類動物脊髓損傷模型的一部分，已經(jīng)有超過100個實驗室在使用它。另外，近超過50%的關于脊髓損傷研究文獻使用的是MASCIS撞擊器。大部分儀器的建議操作程序是源自于Multicenter Animal Spinal Cord Injury Study(MASCIS)模型和實際工作經(jīng)驗。
現(xiàn)有MASCIS撞擊器現(xiàn)在是它的第三代產(chǎn)品，與以前的產(chǎn)品相比已經(jīng)有很多方面的改進提高。現(xiàn)有兩個型號的撞擊器。電腦版撞擊器(Model I)可以記錄數(shù)據(jù)。同時也可以使用基本版撞擊器(The Rutgers Impactor,Model II)僅進行撞擊， 不記錄數(shù)據(jù)。
電腦版撞擊器可以精確測量一個10克的小棒的運動情況，這個小棒從12.5mm，25mm，50mm高處落到術后暴露的脊髓T9-10處。另外設備還可以測量撞擊位置脊柱的運動。顯示墜落小棒的軌跡，并測量撞擊速度（ImpV），脊髓壓縮距離（Cd），脊髓壓縮時間(Ct)，脊髓壓縮率(Cr)。這些撞擊參數(shù)本身是相關的，同時與其它的脊髓損傷數(shù)值如組織Na，K濃度，運動恢復locomotor recovery(BBB 評分)也是相關的。
大小鼠的撞擊都需要一個固定系統(tǒng)(Clamping systems)。同時還需要一個CS-tie。
Model II
Model I
參考文獻
1:Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion.
Hyun JK, Lee YI, Son YJ, Park JS.
Department of Rehabilitation Medicine, Dankook University, Cheonan, Korea. rhhyun@dankook.ac.kr
2:A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model.
Pinzon A, Marcillo A, Quintana A, Stamler S, Bunge MB, Bramlett HM, Dietrich WD.
Brain Res. 2008 Dec 3;1243:146-51. Epub 2008 Sep 24.
3 :The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury.
Cramer SW, Baggott C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D.
Mol Pain. 2008 Sep 17;4:36.
4:Novel combination strategies to repair the injured mammalian spinal cord.
Bunge MB.
J Spinal Cord Med. 2008;31(3):262-9. Review.
5:A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury.
Pinzon A, Marcillo A, Pabon D, Bramlett HM, Bunge MB, Dietrich WD.
Exp Neurol. 2008 Sep;213(1):129-36. Epub 2008 Jul 14.
6: B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury.
DomBourian MG, Turner NA, Gerovac TA, Vemuganti R, Miranpuri GS, Türeyen K, Satriotomo I, Miletic V, Resnick DK.
Spine. 2006 Nov 15;31(24):2778-82.
7:Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord.
Casella GT, Bunge MB, Wood PM.
Exp Neurol. 2006 Nov;202(1):8-20. Epub 2006 Jul 26.
8:Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord.
Himes BT, Neuhuber B, Coleman C, Kushner R, Swanger SA, Kopen GC, Wagner J, Shumsky JS, Fischer I.
Neurorehabil Neural Repair. 2006 Jun;20(2):278-96.
9:Mechanical and cold allodynia in a rat spinal cord contusion model.
Yoon YW, Dong H, Arends JJ, Jacquin MF.
Somatosens Mot Res. 2004 Mar;21(1):25-31.
10:Spinal cord contusion models.
Young W.
Prog Brain Res. 2002;137:231-55. Review.
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