Oligomycin (Synonyms: 寡霉素)
Oligomycin 是一種抗真jun抗生su,是 H+-ATP 合成酶的抑制劑。Oligomycin 斷氧化磷酸化和電子傳遞鏈。Oligomycin 抑制缺氧性腫瘤細(xì)胞 HIF-1alpha 表達(dá)。
生物活性
Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells
體外研究(In Vitro)
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis[1].
性狀:Solid
CAS 號(hào):1404-19-9
中文名稱:寡霉素
來源
Streptomyces
運(yùn)輸條件
Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
-20°C, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性數(shù)據(jù)
In Vitro:
Ethanol : 30 mg/mL (Need ultrasonic and warming)
DMSO : 20 mg/mL (Need ultrasonic and warming)
參考文獻(xiàn)
[1]. Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796. [Content Brief]
[2]. SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970. [Content Brief]
[3]. López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976. [Content Brief]
[4]. Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029. [Content Brief]
[5]. Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157. [Content Brief]
注:產(chǎn)品僅用于科研