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(±)-Carnitine chloride

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  • 公司名稱杭州昊鑫生物科技股份有限公司
  • 品       牌MCE
  • 型       號(hào)HY-B1453
  • 所  在  地杭州市
  • 廠商性質(zhì)代理商
  • 更新時(shí)間2024/7/9 16:45:34
  • 訪問次數(shù)86
產(chǎn)品標(biāo)簽:

DL-Carnitine chloride

規(guī)格
500mg400.00元10000 支可售
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杭州昊鑫生物科技股份有限公司成立于2009年初，是一家面向生命科學(xué)領(lǐng)域，從事科研機(jī)構(gòu)、高校、院所及生產(chǎn)企業(yè)所需科研試劑、耗材，儀器銷售和服務(wù)面向全國(guó)。

產(chǎn)品和服務(wù)涵蓋生命科學(xué)研究技術(shù)的諸多方面，提供覆蓋分子生物學(xué)、細(xì)胞生物學(xué)、植物學(xué)、生物化學(xué)、蛋白組學(xué)、免疫學(xué)等領(lǐng)域的實(shí)驗(yàn)產(chǎn)品以及生物技術(shù)服務(wù)等。目前一級(jí)代理品牌有：MCE（Medchemexpress）、Biochannel、AATbio、invivogen、Abnova、Atlas、Origene、Biovision、云克?。–loud-clone）、艾德萊(Aidlab)、Cayman、Jackson、Epigentek、Prospec、Sciencell、icellbioscience（賽百慷）、hkABCbio、chondrex、Mybiosource、Abbexa、Innovrsrch、HPI、Hitobiotec、Greerlabs，Ostex，4ADI，LDN等。

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胎牛血清、MCE抑制劑激動(dòng)劑、RNA提取試劑盒、ELISA試劑盒、重組蛋白
CAS號(hào) 461-05-2 產(chǎn)地 國(guó)產(chǎn)
規(guī)格 500mg 級(jí)別 化工級(jí)
證書 ISO系列證書
(±)-Carnitine chloride 有D和L兩種異構(gòu)體。L-carnitine在脂肪酸的β-氧化中起重要作用，也具有抗氧化作用和抗yan活性。
(±)-Carnitine chloride 產(chǎn)品信息

(±)-肉堿氯化物  (Synonyms: DL-Carnitine chloride)

(±)-Carnitine chloride 有D和L兩種異構(gòu)體。L-carnitine在脂肪酸的β-氧化中起重要作用，也具有抗氧化作用和抗yan活性。

生物活性

(±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.


體外研究(In Vitro)

The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine[1]. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells. L-carnitine protects HL7702 cells against H2O2-induced cell damage through Akt-mediated activation of Nrf2 signaling pathway[2].


體內(nèi)研究(In Vivo)

L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy[3]. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ[4].


分子量：197.66


Formula：C7H16ClNO3


CAS 號(hào)：461-05-2


中文名稱：混旋肉堿鹽酸鹽；DL-肉堿鹽酸鹽


來源：Human muscle


運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.


儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)



溶解性數(shù)據(jù)


In Vitro:

H2O : ≥ 100 mg/mL (505.92 mM)

DMSO : 25 mg/mL (126.48 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
1 mM5.0592 mL25.2960 mL50.5919 mL
5 mM1.0118 mL5.0592 mL10.1184 mL
10 mM0.5059 mL2.5296 mL5.0592 mL
*

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.


    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 150 mg/mL (758.88 mM); Clear solution; Need ultrasonic


  • 2.


    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution


  • 3.


    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution


  • 4.


    請(qǐng)依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.65 mM); Clear solution


參考文獻(xiàn)

  • [1]. Oyanagi E, et al. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acidstress. Biochem Biophys Res Commun. 2011 Aug 19;412(1):61-7.  [Content Brief]

    [2]. Li J, et al. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can J Physiol Pharmacol. 2016 May;94(5):517-25.  [Content Brief]

    [3]. Jang J, et al. l-Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats. Appl Physiol Nutr Metab. 2016 Dec;41(12):1240-1247.  [Content Brief]

    [4]. Zambrano S, et al. L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. Am J Hypertens. 2014 Mar;27(3):460-70.  [Content Brief]

注：產(chǎn)品僅用于科研



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