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Recombinant Murine β-NGF
別名:
none
描述:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers （240 total amino acid residues）. The three disulfide bonds are required for biological activity.
氨基酸序列:
MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G
來源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
交叉反應(yīng):
Human
研究領(lǐng)域:
 | 血管生成/ 心血管 |  | 趨化 |
 | 糖尿病/ 體重調(diào)節(jié) |  | 炎癥 |
 | 神經(jīng)生物學(xué) |  | 干細胞及分化 |
 | 創(chuàng)傷修復(fù) |
原產(chǎn)國:
USA
僅用于研究。不適用于診斷或治療。
產(chǎn)品包裝：
