無(wú)線光遺傳設(shè)備

光遺傳學(xué)（optogenetics）——結(jié)合遺傳工程與光來(lái)操縱個(gè)別神經(jīng)細(xì)胞的活性。這方法有助于發(fā)展一系列腦相關(guān)失調(diào)的新療法。

Teleopto無(wú)線光遺傳學(xué)刺激器由耦合了高精度LED光源的無(wú)線光導(dǎo)纖維，遠(yuǎn)程控制器，接收器及相關(guān)配件組成。

高精度LED光源的光導(dǎo)纖維是高亮度的LED燈源和光導(dǎo)纖維耦合而成，實(shí)現(xiàn)輸出功率達(dá)到mW級(jí)。應(yīng)用這個(gè)技術(shù)可以獲取高精度的LED光源。所需光源顏色不同，選擇不同的光導(dǎo)纖維。

無(wú)線光遺傳學(xué)刺激器突破了傳統(tǒng)的有線刺激，解放了動(dòng)物，使其不再受到連接線帶來(lái)的束縛，動(dòng)物可以自由活動(dòng)，使其處于更自然的狀態(tài)下，有利于實(shí)驗(yàn)獲取精準(zhǔn)的數(shù)據(jù)。

• 實(shí)驗(yàn)動(dòng)物自由活動(dòng)，不受束縛

• 通過(guò)紅外遙控操作

• 適用于大鼠和小鼠

• 接收器體積微小且輕便

• 兼容性強(qiáng)

• 光源精度高，穩(wěn)定

• 多種光源顏色可選

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction.

Roger Marek, Li Xu, Robert K. P. Sullivan, Pankaj Sah

Nature Neuroscience (2018) 21(5):654-658. DOI: 10.1038

Top-down cortical input during NREM sleep consolidates perceptual memory.

Miyamoto D, Hirai D, Fung CCA, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M

Science (2016) 352(6291): 1315-8. DOI: 10.1126

Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.

Isosaka T, Matsuo T, Yamaguchi T, Funabiki K, Nakanishi S, Kobayakawa R, Kobayakawa K

Cell (2015) 163(5):1153-64

A Top-Down Cortical Circuit for Accurate Sensory Perception.

Manita S, Suzuki T, Homma C, Matsumoto T, Odagawara M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, Murayama M

Neuron (2015) 86:1304-16

The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.

Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F

Molecular Brain (2015) 8:22