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Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子

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公司名稱北京方程嘉鴻科技有限公司
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更新時(shí)間2016/2/4 15:02:43
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Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子

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Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子產(chǎn)品信息

Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細(xì)胞因子受體主要分為四種類型：免疫球蛋白超家族（IGSF）、造血細(xì)胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

Catalog Number:

300-01A

Synonyms:

Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor （DIF）, Necrosin, Cytotoxin

Description:

TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein （17.4 kDa） which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

AA Sequence:

VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

Cross Reactivity:

Cow, Monkey, Mouse, Rat, Sheep, Human, Bacteria, Human + Rat, Pig, Dog

Research Interests:

	AIDS / HIV		Angiogenesis/ Cardiovascular
	Apoptosis		Cancer
	Diabetes / Weight Regulation		Immune System
	Inflammation		Neurobiology
	Stem Cells & Differentiation		TNF Superfamily
	Allergy		Transplantation