Recombinant Human TSLP 貨號(hào):300-62 細(xì)胞因子
胞因子受體存在著可溶性形式，掌握可溶性細(xì)胞因子受體產(chǎn)生的規(guī)律及其生理和病理意義，必將擴(kuò)展人們對(duì)細(xì)胞因子網(wǎng)絡(luò)作用的認(rèn)識(shí)。檢測(cè)細(xì)胞因子及其受體的水平已成為基礎(chǔ)和臨床免疫學(xué)研究中的一個(gè)重要的方面。Catalog Number:
Catalog Number:
300-62
Synonyms:
Thymic Stromal Lymphopoietin
Description:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R α chain （IL-7Rα） and the TSLP-specific chain （TSLPR）. Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia （AML）-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c（+） dendritic cells （DCs）. TSLP activated DCs primed naïve T cells to produce the proallergic cytokines （IL-4, IL-5, IL-13, TNFα） while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
AA Sequence:
MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data not available at this time.
Cross Reactivity:
Mouse, Human
Research Interests:
 | Apoptosis |  | Inflammation |
Country of Origin:
USA
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