Afoxolaner 是一種具有口服活性的，對犬肩蜥的異惡唑啉殺蟲劑/殺螨劑。Afoxolaner 作用于昆蟲的 γ-氨基丁酸受體 (GABA) 和谷氨酸受體 (glutamate receptors)，抑制 GABA 和谷氨酸調(diào)節(jié)的氯離子 (chloride ions) 吸收，導致過度的神經(jīng)元刺激和節(jié)肢動物死亡。
英文別名:
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
Fluralaner, also known as AH252723, is a systemic insecticide and acaricide that is administered orally. The US Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and l-glutamate-gated chloride channels (GluCls).
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